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Crystal Palace secured a 2-0 win over Manchester United at Old Trafford, with Jean-Philippe Mateta scoring both goals on Sunday.
United’s woes were compounded by a serious injury to defender Lisandro Martinez, who was stretchered off in tears after sustaining a knee injury.
The incident caused a lengthy delay as medics attended to the Argentine international.
Martinez’s injury is a significant setback for United, as the defender previously endured a long spell on the sidelines after breaking his metatarsal in his debut season at the club.
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Mateta opened the scoring for Palace in the 64th, putting the visitors ahead.
His second goal came shortly just before full-time.
The loss leaves Manchester United manager Ruben Amorim with mounting concerns, as his side struggles for consistency in the Premier League.